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Jason Plemel began his training in the laboratory of Dr. Wolfram Tetzlaff where he completed his Doctorate. There he investigated two separate strategies to improve white matter regeneration: transplantation of precursor cells to replace lost oligodendrocytes and cell culture to find novel targets to improve remyelination. During Dr. Plemel’s postdoctoral work he studied the contribution of microglia following myelin injury in the laboratories of Dr. Peter Stys and Dr. Wee Yong. His interdisciplinary project investigated mechanisms of how immune cells respond to primary degeneration and developed a new tool to image cell death and injury using spectral microscopy. In his new faculty appointment at the University of Alberta, Dr. Plemel and his laboratory will investigate how microglia play an important role in the regeneration of injured white matter, but also how microglia can induce injury to white matter during different disease conditions.
Roles and Connections
Most Cited Publications
|Faissner S, Plemel JR, Gold R, Yong VW, "Progressive multiple sclerosis: from pathophysiology to therapeutic strategies." Nature reviews. Drug discovery 18,12 (2019 Dec): 905-922|
|Plemel JR, Stratton JA, Michaels NJ, Rawji KS, Zhang E, Sinha S, Baaklini CS, Dong Y, Ho M, Thorburn K, Friedman TN, Jawad S, Silva C, Caprariello AV, Hoghooghi V, Yue J, Jaffer A, Lee K, Kerr BJ, Midha R, Stys PK, Biernaskie J, Yong VW, "Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion." Science advances 6,3 (2020 Jan): eaay6324|
|Rawji KS, Young AMH, Ghosh T, Michaels NJ, Mirzaei R, Kappen J, Kolehmainen KL, Alaeiilkhchi N, Lozinski B, Mishra MK, Pu A, Tang W, Zein S, Kaushik DK, Keough MB, Plemel JR, Calvert F, Knights AJ, Gaffney DJ, Tetzlaff W, Franklin RJM, Yong VW, "Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system." Acta neuropathologica 139,5 (2020 May): 893-909|