About

Name

Jong Rho

University

University of Calgary

Website

research4kids.ucalgary.ca/profiles/jong-m-rho

Email

[email protected]

Research Keywords

mitochondial bioenergetics and brain metabolism, animal models of pediatric epilepsy, mechanisms of ketogenic diet action, rodent models of autism spectrum disorder, ion channel pharmacology and physiology, epilepsy experimental therapeutics, video EEG

Additional Information

Lab Methodologies
  • Video EEG
  • Electrophyisiolgy
  • single channel and slice recordings
  • Behavior
  • Bioenergetics
  • Seahorse OCR and ECAR
  • Immunohistochemistry
  • Confocal Microscopy
  • Molecular biology

 

Apparatus
  • Seahorse XF24 Flux Analyzer
  • Electrophysiolgy Rigs
  • Chemi-doc
  • PCR
  • Real Time PCR
  • Confocal
  • Video EEG

 

Biographical Information

The major goal of our research laboratory is to elucidate the molecular and cellular mechanisms responsible for the anti-seizure effects of the ketogenic diet (KD), a high-fat and low-carbohydrate treatment for medically refractory epilepsy. Further, our laboratory is pursuing investigations aimed at demonstrating the broad neuroprotective (and possibly disease-modifying) effects of the KD in a variety of animal models of neurological disorders

Roles and Connections

Primary Role

Faculty

CAN Connections

Nervous System Injury

Looking For

Accepting graduate students, Accepting postdoctoral fellows

Most Cited Publications

Gano LB, Patel M, Rho JM, "Ketogenic diets, mitochondria, and neurological diseases." Journal of lipid research 55,11 (2014 Nov): 2211-28
Newell C, Bomhof MR, Reimer RA, Hittel DS, Rho JM, Shearer J, "Ketogenic diet modifies the gut microbiota in a murine model of autism spectrum disorder." Molecular autism 7,1 (2016): 37
Kim DY, Simeone KA, Simeone TA, Pandya JD, Wilke JC, Ahn Y, Geddes JW, Sullivan PG, Rho JM, "Ketone bodies mediate antiseizure effects through mitochondrial permeability transition." Annals of neurology 78,1 (2015 Jul): 77-87